Symptoms of bone cancer vary from person to person and depending on the location and size of the cancer. The most common symptoms are pain and swelling or tenderness in the affected area. Sometimes bone cancer can interfere with movement and can weaken the bones, occasionally leading to a fracture. Other symptoms of cancer may include tiredness, fever, weight loss, and anemia. None of these symptoms is a sure sign of cancer; if you suspect you have a health problem consult your doctor.